147 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28182408	126	Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.	Universit£
27189675	38	The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors.	Janssen Pharmaceutical Companies of Johnson & Johnson
27130358	67	Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.	E.I. Du Pont De Nemours
27117424	7	Design, synthesis and biological evaluation of potent FAAH inhibitors.	Univ. Lille
26888301	34	Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.	University of Siena
26344596	66	Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors.	University of Eastern Finland
25282655	51	Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).	University of Eastern Finland
26002335	55	Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH).	Universit£
25752982	26	Loratadine analogues as MAGL inhibitors.	University of Eastern Finland
25701254	48	Novel tail and head group prostamide probes.	Northeastern University
24972328	26	Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii.	University of Szeged
25467164	20	Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.	Roseman University of Health Sciences
24944750	24	Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.	Merck Research Laboratories
24690529	43	a-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.	The Scripps Research Institute
24456116	105	Design, synthesis, and characterization ofa-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase.	The Scripps Research Institute
24513048	88	1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.	Janssen Pharmaceutical Companies of Johnson & Johnson
24508127	19	Switching cannabinoid response from CB(2) agonists to FAAH inhibitors.	University of Lille
24440478	22	Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.	Takeda Pharmaceutical
24433863	76	Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase.	Janssen Research and Development
24083878	61	Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.	University of Eastern Finland
23891163	30	Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition.	Mcphs University
24900701	36	Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.	Merck Research Laboratories
23455058	84	(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).	University of M£Nster
23237837	14	Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.	Universit£
23218778	49	Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.	Takeda Pharmaceutical
23287055	20	An unprecedented reversible mode of action ofß-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH).	Universit£
19883085	86	Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.	Universite Catholique De Louvain
15482935	1	Synthesis of 61-bis(1-adamantylcarbamoyl)-1,2-methano[60]fullerene and its antagonistic effect on haloperidol-induced catalepsy in mice.	Kyushu University
23141911	60	Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.	Janssen Research and Development
21413808	170	Synopsis of some recent tactical application of bioisosteres in drug design.	Bristol-Myers Squibb Pharmaceutical Research and Development
23116186	68	Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).	Astrazeneca
22779702	53	Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.	Universit£
24900385	51	Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.	TBA
23036333	77	Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold.	Sapienza University of Rome
22651858	74	Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors.	Universit£
21899370	15	SAR and LC/MS studies ofß-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process.	Universit£
24900454	43	The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?	TBA
21666860	14	Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.	Pfizer
18983142	135	Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.	Johnson & Johnson Pharmaceutical Research and Development
18657971	14	Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling.	The Scripps Research Institute
18630870	236	Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.	Institute For Chemical Biology
18053726	364	Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.	Johnson & Johnson Pharmaceutical Research & Development
18247553	174	Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.	The Scripps Research Institute
18023188	86	Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).	University of California
18289847	35	Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).	Johnson & Johnson Pharmaceutical Research and Development
17279740	191	Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.	The Scripps Research Institute
16078824	48	The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.	Universit£
22209458	114	Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.	Vernalis (R&D)
22196515	14	Design, synthesis and evaluation of polar head group containing 2-keto-oxazole inhibitors of FAAH.	Max Planck Institute of Molecular Physiology
22056744	16	Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.	Universit£
21764305	79	The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).	The Scripps Research Institute
21612933	17	New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.	University of Lille
21428410	78	Reversible competitivea-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.	The Scripps Research Institute
21392988	87	Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.	Amgen
19029917	5	Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.	The Scripps Research Institute
18438404	13	Activation of the endocannabinoid system by organophosphorus nerve agents.	University of California
19088712	1	Decoding endocannabinoid signaling.	TBA
20591666	66	A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.	Università
19850474	5	Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.	Renovis
20036536	79	Oxime carbamate--discovery of a series of novel FAAH inhibitors.	Bristol-Myers Squibb Research & Development
20099888	105	Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.	The Scripps Research Institute
19924997	2	X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.	The Scripps Research Institute
19583260	102	Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.	Louvain Drug Research Institute
19877691	36	beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase.	Universite Catholique De Louvain
19515560	24	Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.	Vernalis (R&D)
18752948	34	Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels.	University of California
18693015	85	Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.	Johnson & Johnson Pharmaceutical Research and Development
18644727	12	Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.	The Scripps Research Institute
18547805	6	3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors.	Université
15771430	129	Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.	The Scripps Research Institute
15713400	99	Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.	The Scripps Research Institute
12951114	18	Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors.	University of California
12166944	48	Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase.	Utrecht University
32334914	5	The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL).	Janssen Research & Development
32527545	27	The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors.	Janssen Research & Development
32216992	31	Discovery of heterocyclic carbohydrazide derivatives as novel selective fatty acid amide hydrolase inhibitors: design, synthesis and anti-neuroinflammatory evaluation.	China Pharmaceutical University
32429662	39	Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors.	China Pharmaceutical University
31761726	56	Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors.	Northeastern University
30816712	78	Plant-Based Modulators of Endocannabinoid Signaling.	Concordia University Wisconsin
30715876	58	Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor.	University of Pisa
31618024	26	Structure-Activity Relationships of Fish Oil Derivatives with Antiallergic Activity in Vitro and in Vivo.	Ehime University
31404862	138	Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.	Palack£
31518969	59	Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems.	University of Siena
30503633	73	Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.	Advinus Therapeutics
31629610	96	Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology.	Northeastern University
9871570	25	An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase.	Institute For Chemical Biology
32176488	48	Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors.	University of Illinois At Chicago
31401465	52	Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.	Julius Maximilian University of W£Rzburg
31407888	4	New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation.	Universit£
30879861	126	N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases.	The Scripps Research Institute
30144699	53	Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.	University of Pisa
30251836	24	Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors.	Takeda Pharmaceutical
29366648	98	Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.	University of California Davis
29079014	25	Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.	University of Pisa
27766867	109	Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.	Universit£
29793210	91	Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.	University of Bern
29856219	11	Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides.	TBA
28535469	69	Novel propanamides as fatty acid amide hydrolase inhibitors.	University of Cagliari
28284861	27	Biological evaluation of pyridone alkaloids on the endocannabinoid system.	University of Bern
29498843	28	Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.	Pfizer
29309142	36	Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.	University of Ferrara
29148769	22	Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.	Pfizer
24831513	35	Functionalization of ß-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System.	University of Bern
21728345	8	Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency.	Astrazeneca Pharmaceuticals
17459705	26	Novel inhibitors of fatty acid amide hydrolase.	Bristol-Myers Squibb
17949010	16	Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.	Pfizer
16866524	4	The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.	The Scripps Research Institute
17559203	161	Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.	The Scripps Research Institute